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SAM-e, also known as S-Adenosyl-L-methionine, is a chemical that is responsible for a multitude of different body functions, most importantly, the synthesis of hormones, detoxification pathways, and brain function.
Supplementing with SAM-e may help with depression, heart disease, fibromyalgia symptoms, tendonitis, dementia, joint pain, mental performance, and help slow the aging process (and then some) according to WebMD.
In 2002, the U.S. Department of Health and Human Services conducted an evaluation of SAM-e and endorsed the efficacy of SAM-e for stable mood and joint function and without side effects.